The New York Stock Exchange (NYSE) closed lower on Tuesday, after two consecutive rises, amid concerns about the rising number of COVID-19 cases and ahead of the first of three presidential debates.
Three debates between incumbent President Donald Trump and the Democratic Party nominee Joe Biden will be held before voters head to the polls on November 3.
The Dow Jones Industrial Average declined by 131.4 points, or 0.48%, to close at the level of 27,452.66 points.
The S&P 500 also lost 0.48%, or 16.13 points, and finished at 3,335.47 points.
Meanwhile, the Nasdaq Composite lost 32.3 points, 0.29%, and ended the second session of the week at the level of 11,085.25 points.